PET imaging of brain amyloid in dementia: a review
Identifieur interne : 000215 ( Main/Exploration ); précédent : 000214; suivant : 000216PET imaging of brain amyloid in dementia: a review
Auteurs : Harriet Quigley [Royaume-Uni] ; Sean J. Colloby [Royaume-Uni] ; John T. O'Brien [Royaume-Uni]Source :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2011-10.
English descriptors
Abstract
Objective: To review the rapidly expanding literature of amyloid PET imaging with particular attention to Pittsburgh compound‐B (PIB) in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), fronto‐temporal dementia (FTD), mild cognitive impairment (MCI) and cognitively normal volunteers. Design: Literature searches were performed using Medline up to February 2010. Individual articles were then examined for additional references not revealed by automated searches. This yielded 79 articles whose abstracts were read by the authors to select key papers. Results: Amyloid deposition assessed using PIB‐PET is significantly elevated in AD and DLB compared to controls and those with FTD. In MCI, uptake is often intermediate between AD and normal ageing, and excessive amyloid burden in non‐demented individuals with MCI are likely to represent high‐risk cases. Amyloid deposition appears to be an early event, and as dementia progresses clinical decline seems to be more associated with neurodegeneration than amyloid burden. Conclusions: PIB‐PET imaging is a sensitive and specific marker for underlying Aβ amyloid deposition and represents an important investigative tool for examining the relationship between amyloid burden, clinical symptoms and structural and functional changes in dementia. Amyloid imaging may also be useful for selecting patients for anti‐amyloid therapies. However, studies have identified PIB‐positive cases in otherwise healthy older individuals (10–30%), limiting diagnostic specificity. Development of biomarkers for investigating other aspects of dementia pathology, i.e. soluble Aβ, tau, synuclein and brain inflammation would further inform our understanding and assist in studying disease‐modifying and preventive treatments in dementia. Copyright © 2010 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/gps.2640
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">PET imaging of brain amyloid in dementia: a review</title><author><name sortKey="Quigley, Harriet" sort="Quigley, Harriet" uniqKey="Quigley H" first="Harriet" last="Quigley">Harriet Quigley</name></author><author><name sortKey="Colloby, Sean J" sort="Colloby, Sean J" uniqKey="Colloby S" first="Sean J." last="Colloby">Sean J. Colloby</name></author><author><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3A0A8481AFD553AF1B7605E520401949AC8760D5</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/gps.2640</idno><idno type="url">https://api.istex.fr/document/3A0A8481AFD553AF1B7605E520401949AC8760D5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002752</idno><idno type="wicri:Area/Main/Curation">002409</idno><idno type="wicri:Area/Main/Exploration">000215</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">PET imaging of brain amyloid in dementia: a review</title><author><name sortKey="Quigley, Harriet" sort="Quigley, Harriet" uniqKey="Quigley H" first="Harriet" last="Quigley">Harriet Quigley</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Colloby, Sean J" sort="Colloby, Sean J" uniqKey="Colloby S" first="Sean J." last="Colloby">Sean J. Colloby</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="991">991</biblScope><biblScope unit="page" to="999">999</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">3A0A8481AFD553AF1B7605E520401949AC8760D5</idno><idno type="DOI">10.1002/gps.2640</idno><idno type="ArticleID">GPS2640</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MCI</term><term>PET</term><term>ageing</term><term>amyloid</term><term>dementia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To review the rapidly expanding literature of amyloid PET imaging with particular attention to Pittsburgh compound‐B (PIB) in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), fronto‐temporal dementia (FTD), mild cognitive impairment (MCI) and cognitively normal volunteers. Design: Literature searches were performed using Medline up to February 2010. Individual articles were then examined for additional references not revealed by automated searches. This yielded 79 articles whose abstracts were read by the authors to select key papers. Results: Amyloid deposition assessed using PIB‐PET is significantly elevated in AD and DLB compared to controls and those with FTD. In MCI, uptake is often intermediate between AD and normal ageing, and excessive amyloid burden in non‐demented individuals with MCI are likely to represent high‐risk cases. Amyloid deposition appears to be an early event, and as dementia progresses clinical decline seems to be more associated with neurodegeneration than amyloid burden. Conclusions: PIB‐PET imaging is a sensitive and specific marker for underlying Aβ amyloid deposition and represents an important investigative tool for examining the relationship between amyloid burden, clinical symptoms and structural and functional changes in dementia. Amyloid imaging may also be useful for selecting patients for anti‐amyloid therapies. However, studies have identified PIB‐positive cases in otherwise healthy older individuals (10–30%), limiting diagnostic specificity. Development of biomarkers for investigating other aspects of dementia pathology, i.e. soluble Aβ, tau, synuclein and brain inflammation would further inform our understanding and assist in studying disease‐modifying and preventive treatments in dementia. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Quigley, Harriet" sort="Quigley, Harriet" uniqKey="Quigley H" first="Harriet" last="Quigley">Harriet Quigley</name></noRegion><name sortKey="Colloby, Sean J" sort="Colloby, Sean J" uniqKey="Colloby S" first="Sean J." last="Colloby">Sean J. Colloby</name><name sortKey="O Brien, John T" sort="O Brien, John T" uniqKey="O Brien J" first="John T." last="O'Brien">John T. O'Brien</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000215 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000215 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:3A0A8481AFD553AF1B7605E520401949AC8760D5
|texte= PET imaging of brain amyloid in dementia: a review
}}
| This area was generated with Dilib version V0.6.23. |  |